PHDS HEALTHCARE RESEARCH Co., Ltd.
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Global standards and quality systems, one-stop drug discovery and preclinical research services and solutions.
Preclinical development
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Preclinical development
Excellent preclinical research services
Preclinical research: A solid foundation for drug development
At PHDS, we understand the core position of preclinical research in the development of drugs and medical devices. Our professional team is dedicated to comprehensively assessing the safety, efficacy, and mechanisms of action of products through a series of precise experimental studies before human clinical trials.
I. Research Objectives
Comprehensive safety assessment:
Our services include comprehensive safety assessments of potential drugs or devices, covering multiple aspects such as acute toxicity, chronic toxicity, and genotoxicity. Through animal experiments and cell models, we accurately observe the effects of drugs on vital organs to ensure the safety of drugs or devices entering clinical trials.
Preliminary exploration of efficacy:
We preliminarily explore the biological effects of drugs or devices through in vitro and in vivo experiments, verifying their effects on specific targets to ensure they can produce the expected therapeutic effects.
II. Research Content
Pharmacological Research:
- Drug target validation:We precisely identify the targets of drug action through cell experiments and assess their impact on related targets such as blood glucose regulation.
- Drug activity screening:We screen for active compounds and observe their effects on cancer cell proliferation and apoptosis.
Toxicological Research:
- Acute toxicity testing:We assess the acute toxicity strength of drugs and calculate the median lethal dose (LD50).
- Chronic toxicity testing:We observe the long-term effects of drugs on animal growth, development, and physiological functions.
- Special toxicity testing:We conduct genotoxicity, reproductive toxicity, and carcinogenicity tests to comprehensively assess the potential risks of drugs.
Pharmacokinetic Research:
- We study the absorption, distribution, metabolism, and excretion (ADME) processes of drugs in vivo, using techniques such as high-performance liquid chromatography to analyze changes in drug concentration within the body.
III. Research Models
Cell models:We utilize human liver cancer cell line HepG2 and other cell models to study the impact of drugs on liver cell metabolic functions.
Animal models:We use various animal models such as mice, rats, dogs, and monkeys to simulate human diseases and drug responses, providing clients with comprehensive animal testing services from rodents to non-rodents.
IV. Service Advantages
Significance:Our preclinical research provides critical data support for clinical trials, screening potential drugs and devices while reducing safety issues in human trials.
Limitations:We are well aware that there are differences between animal models and human beings; therefore, our services emphasize the scientific nature and clinical relevance of data to ensure the accuracy and reliability of research results.
PHDS Professional Team Consulting Services
The professional team at PHDS offers the following consulting services:
1. Strict adherence to GCP and SOP standard operating procedures.
2. Selection of clinical sites and management of multi-center trials.
3. Clinical project prospect analysis and project management.
4. Clinical protocol writing and drug distribution.
5. Subject recruitment.
6. Clinical service monitoring.
7. Data collection and statistical analysis.
8. Preparation of clinical submission materials.
Choose PHDS to accelerate your drug development process
We understand the complexity of preclinical research and the demands for precision. PHDS's one-stop service aims to simplify processes, improve efficiency, and ensure your project can progress quickly and smoothly. Choosing us means choosing a trustworthy partner; we will work hand in hand with you to drive the success of drug development.
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Contact Information
Customer service hotline:
E-mail:customer@cnphds.com
Address: Building A, Ocean Express,66 Xia Guang Li, Dong San Huan North Road,Chaoyang district, Beijing, China
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